Vitamin B12 Deficiency and Metformin

References on vitamin B12 deficiency and the use of Metformin 

Kumthekar AA, Gidwani HV, Kumthekar AB. Metformin associated B12 deficiency. J Assoc Physicians India. 2012 Mar;60:58-60.

Mazokopakis EE, Starakis IK. Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency. Diabetes Res Clin Pract. 2012 Jul 7. [Epub ahead of print]

Moore E, Mander A, Ames D, Carne R, Sanders K, Watters D. Cognitive impairment and vitamin B12: a review. Int Psychogeriatr. 2012 Jan 6:1-16. [Epub ahead of print]

Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr. Association of biochemical B₁₂ deficiency with metformin therapy and vitamin B₁₂ supplements: the National Health and Nutrition Examination Survey, 1999-2006. Diabetes Care. 2012 Feb;35(2):327-33. Epub 2011 Dec 16. (VB12 supplements may not be enough)

Kos E, Liszek MJ, Emanuele MA, Durazo-Arvizu R, Camacho P. Effect of metformin therapy on vitamin D and vitamin B12 levels in patients with type 2 diabetes mellitus. Endocr Pract. 2012 Mar-Apr;18(2):179-84.

Moore E, Mander A, Watters D. More adverse neurological consequences of metformin-induced vitamin B12 deficiency. South Med J. 2011 Jul;104(7):541-2; author reply 542.

Sando KR, Barboza J, Willis C, Taylor J. Recent diabetes issues affecting the primary care clinician. South Med J. 2011 Jun;104(6):456-61. Review.

Langan RC, Zawistoski KJ. Update on vitamin B12 deficiency. Am Fam Physician. 2011 Jun 15;83(12):1425-30.

Nervo M, Lubini A, Raimundo FV, Faulhaber GA, Leite C, Fischer LM, Furlanetto TW. Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil. Rev Assoc Med Bras. 2011 Jan-Feb;57(1):46-9.

Mahajan R, Gupta K. Revisiting Metformin: Annual Vitamin B12 Supplementation may become Mandatory with Long-Term Metformin Use. J Young Pharm. 2010 Oct;2(4):428-9.

Bundrick JB, Litin SC. Clinical pearls in general internal medicine. Mayo Clin Proc. 2011 Jan;86(1):70-4. No abstract available.

Diabetes drug interferes with vitamin B12. Harv Heart Lett. 2010 May;20(9):7. No abstract available.

Vidal-Alaball J, Butler CC. Reduced serum vitamin B-12 in patients taking metformin. BMJ. 2010 May 20;340:c2198. doi: 10.1136/bmj.c2198. No abstract available.

de Jager J, Kooy A, Lehert P, Wulffelé MG, van der Kolk J, Bets D, Verburg J, Donker AJ, Stehouwer CD. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ. 2010 May 20;340:c2181. doi: 10.1136/bmj.c2181.

Berlie HD, Garwood CL. Diabetes medications related to an increased risk of falls and fall-related morbidity in the elderly. Ann Pharmacother. 2010 Apr;44(4):712-7.

Tal S, Shavit Y, Stern F, Malnick S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr Soc. 2010 Mar;58(3):523-6. Epub 2010 Feb 11.

Bell DS. Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. South Med J. 2010 Mar;103(3):265-7.

Andrès E, Federici L. Vitamin B12 deficiency in patients receiving metformin: clinical data. Arch Intern Med. 2007 Apr 9;167(7):729


Varughese GI, Tahrani AA, Scarpello JH. The long and short of metformin-related vitamin B12 deficiency. Arch Intern Med. 2007 Apr 9;167(7):729-30

Ting RZ, Szeto CC, Chan MH, Ma KK, Chow KM. Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med. 2006 Oct 9;166(18):1975-9.

Andrès E, Noel E, Goichot B. Metformin-associated vitamin B12 deficiency. Arch Intern Med. 2002 Oct 28;162(19):2251-2. No abstract available.

Gilligan MA. Metformin and vitamin B12 deficiency. Arch Intern Med. 2002 Feb 25;162(4):484-5

Liu KW, Dai LK, Jean W. Metformin-related vitamin B12 deficiency. Age Ageing. 2006 Mar;35(2):200-1.

Buvat DR. Use of metformin is a cause of vitamin B12 deficiency. Am Fam Physician. 2004 Jan 15;69(2):264; author reply 264, 266.

Fujita H, Narita T, Yoshioka N, Hosoba M, Ito S. A case of megaloblastic anemia due to vitamin B12 deficiency precipitated in a totally gastrectomized type II diabetic patient following the introduction of metformin therapy. Endocr J. 2003 Aug;50(4):483-4.

Andrès E, Perrin AE, Demangeat C, Kurtz JE, Vinzio S, Grunenberger F, Goichot B, Schlienger JL. The syndrome of food-cobalamin malabsorption revisited in a department of internal medicine. A monocentric cohort study of 80 patients. Eur J Intern Med. 2003 Jul;14(4):221-226.

Andrès E, Noel E, Goichot B. Metformin-associated vitamin B12 deficiency. Arch Intern Med. 2002 Oct 28;162(19):2251-2. No abstract available.

Gilligan MA. Metformin and vitamin B12 deficiency. Arch Intern Med. 2002 Feb 25;162(4):484-5. No abstract available.

Deutsch JC, Santhosh-Kumar CR, Kolhouse JF. Efficacy of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med. 1996 Jan 25;334(4):269; author reply 269-70.

Berger W. Incidence of severe side-effects during therapy with sulfonylureas and biguanides. Horm Metab Res Suppl. 1985;15:111-5.

Adams JF, Clark JS, Ireland JT, Kesson CM, Watson WS. Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy. Diabetologia. 1983 Jan;24(1):16-8


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